Ban on creating human organs inside bodies of animals likely to be lifted

The Yomiuri Shimbun

The Yomiuri ShimbunA ban on creating human organs inside the bodies of animals will likely be lifted as early as this autumn, following a planned review of the current guidelines prohibiting such research.

An expert panel of the Education, Culture, Sports, Science and Technology Ministry last month compiled a report on research into producing human organs in the bodies of pigs and other animals. In the report, the panel concluded it would allow researchers to implant an animal embryo (a fertilized egg) containing human cells into an animal’s womb and have the animal give birth.

The ministry plans to revise the current guidelines, making it likely that the ban on such studies will be lifted as early as this autumn.

One method being considered for growing human organs inside animal bodies involves injecting human induced pluripotent stem (iPS) cells into an animal embryo and then returning the embryo to an animal’s womb to be birthed. The embryos are genetically modified to prevent specific organs from being created.

Japan’s current guidelines prohibit transplanting such an embryo into an animal’s womb.

The panel pointed out in the latest report that this research could lead to discovering the underlying causes of diseases, securing organs to be used for transplants, and developing new treatments. The panel thus concluded it would be appropriate to allow an animal embryo containing human cells to be transplanted into an animal’s womb to be birthed, considering that such studies have already been allowed in the United States and Britain.

However, the panel in the same report decided not to allow research that could produce a creature ambiguous enough to blur the line between humans and other animals, crossbreeding of animals born as a result of the method, and fertilization using human germ cells.

It also called for ethics committees of the government, universities and research institutions to examine the content of the research before deciding whether to conduct such studies.

A team led by University of Tokyo Prof. Hiromitsu Nakauchi has said it will carry out research to create a human pancreas inside a pig if the ban on the growth of human organs in animals is lifted.Speech

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